fnctId=bbs,fnctNo=2860
- 글번호
- 241544
- 작성일
- 2021.09.18
- 수정일
- 2021.09.19
- 작성자
- 김민걸
- 조회수
- 79
[교신저자] Urinary Metabolomic Profiling after Administration of Corydalis Tuber and Pharbitis Seed Extract in Healthy Korean Volunteers
Pharmacometabolomics is a useful tool to identify biomarkers that can assess and predict response after drug administration. The primary purpose of pharmacometabolomics is to better understand the mechanisms and pathways of a drug by searching endogenous metabolites that have significantly changed after drug administration. DA-9701, a prokinetic agent, consists of Pharbitis seed and Corydalis tube extract and it is known to improve the gastrointestinal motility. Although the overall mechanism of action of DA-9701 remains unclear, its active ingredients, corydaline and chlorogenic acid, act as a 5-HT3 and D2 receptor antagonist and 5-HT4 receptor agonist. To determine the significant metabolites after the administration of DA-9701, a qualitative analysis was carried out using ultra-high performance liquid chromatography coupled with orbitrap mass spectrometer followed by a multivariate analysis. Seven candidates were selected and a statistical analysis of fold change was performed over time. Our study concluded that all the seven selected metabolites were commonly involved in lipid metabolism and purine metabolism.
Keywords: DA-9701; HRMS; metabolomics; natural product extracts; prokinetic agents.
Keywords: DA-9701; HRMS; metabolomics; natural product extracts; prokinetic agents.
- Title
- Urinary Metabolomic Profiling after Administration of Corydalis Tuber and Pharbitis Seed Extract in Healthy Korean Volunteers
- Author
- Jeong HC, Park JE, Seo Y, Kim MG, Shin KH.
- Year
- 2021
- Journal
- Pharmaceutics.
- Details
- 2021 Apr 9;13(4):522
- DOI
- 10.3390/pharmaceutics13040522
- 다음글
-
[교신저자] Pharmacokinetics of a New, Once-Daily, Sustained-Release Pregabalin Tablet in Healthy Male Volunteers김민걸 2021-09-18 23:47:08.0
- 이전글
-
[공저자] Physiologically-based pharmacokinetic model for clozapine in Korean patients with schizophrenia김민걸 2021-09-18 23:46:33.0